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GFP:lamin and mCherry:histone expressing C elegans early embryo

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CNEP-1:GFP is enriched at the nuclear membrane relative to a general mCherry:ER marker.

The Bahmanyar lab is interested in mechanisms that drive nuclear envelope structure, identity, and dynamics. Our research aims to: 1) develop novel tools to study the composition and role of phospholipids in nuclear membrane structure and function;  2) define functions for nuclear lamins during cell division, organismal development, and disease; 3) identify functions for novel inner nuclear membrane proteins in the organization of single cells and complex tissues. We use the nematode C. elegans and human tissue culture cells to address these questions.  Our approaches include high resolution time lapse microscopy, genetics and biochemistry.