C elegans embryo expressing a RFP fusion to an ER marker and a GFP fusion to an enzyme required for phospholipid synthesis.

The Bahmanyar lab is interested in mechanisms that drive organelle structure, identity, and dynamics. Our main aim is to understand how lipid metabolism is coupled to endoplasmic reticulum (ER) structure and dynamics, with a focus on the nuclear envelope subdomain of the ER.  Other areas of interest include the role of nuclear lamins in nuclear dynamics during cell division, organismal development, and disease, and defining functions for inner nuclear membrane proteins in the organization of single cells and complex tissues. We use the nematode C. elegans and human tissue culture cells to address these questions.  Our approaches include high resolution time lapse microscopy, genetics and in vivo biochemistry. 


Twitter: Bahmanyarlab